Search by BoMiProt ID - Bomi5939


Primary Information

BoMiProt ID Bomi5939
Protein Name Gap junction delta-2 protein/Connexin-36/Gap junction alpha-9 protein
Organism Bos taurus
Uniprot IdQ866T7
Milk FractionWhey
Ref Sequence Id NP_777108.1
Aminoacid Length 321
Molecular Weight 36126
Fasta Sequence https://www.uniprot.org/uniprot/Q866T7.fasta
Gene Name GJD2/GJA9
Gene Id 282577
Protein Existence Status reviewed

Secondary Information

Protein Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biochemical Properties gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 114-186, 284-292, 306-321
DisProt Annotation
TM Helix Prediction 4TMHs; (20-42), (76-98), (198 220), (252 270)
Significance of PTMs Two important modulators are dopamine and adenosine which control phosphorylation and dephosphorylation. Cx35/Cx36 remains in a dephosphorylated (uncoupled) state under bright lighting conditions. High-illuminant light inhibits ocular growth through the uncoupling of retinal gap junctions.Light-directed Cx35/36 (de)phosphorylation has been described to be regulated by dopamine signaling (effect: dephosphorylation/uncoupling) and and adenosine signaling (effect: phosphorylation/coupling).
Bibliography 1.Quint, W.H., Tadema, K.C.D., de Vrieze, E. et al. Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Commun Biol 4, 676 (2021). https://doi.org/10.1038/s42003-021-02185-z