Search by BoMiProt ID - Bomi5937


Primary Information

BoMiProt ID Bomi5937
Protein Name Gap junction alpha-3 protein/Connexin-44/Cx44
Organism Bos taurus
Uniprot IdP41987
Milk FractionWhey
Ref Sequence Id NP_001159768.1
Aminoacid Length 407
Molecular Weight 43611
Fasta Sequence https://www.uniprot.org/uniprot/P41987.fasta
Gene Name GJA3
Protein Existence Status reviewed

Secondary Information

Protein Function It is a structural component of gap junctions in lens fiber.
PTMs Disuphide bond, Phosophorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (107-129), (233-406)
DisProt Annotation
TM Helix Prediction 4TMHs ; (20-38), (77-99), (144-166), (199-221)
Significance of PTMs Phosphorylated on multiple threonine and serine residues. Phosphorylation may have a role in assembling connexins into connexons and gap junctional plaques, as well as channel gating
Bibliography Gupta, V. K., Berthoud, V. M., Atal, N., Jarillo, J. A., Barrio, L. C., & Beyer, E. C. (1994). Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression. Investigative ophthalmology & visual science, 35(10), 3747–3758.