Search by BoMiProt ID - Bomi5927


Primary Information

BoMiProt ID Bomi5927
Protein Name Galectin-9/Gal-9
Organism Bos taurus
Uniprot IdQ3MHZ8
Milk FractionWhey
Ref Sequence Id NP_001034266.1
Aminoacid Length 355
Molecular Weight 39334
Fasta Sequence https://www.uniprot.org/uniprot/Q3MHZ8.fasta
Gene Name LGALS9
Gene Id 510813
Protein Existence Status reviewed

Secondary Information

Protein Function Binds galactosides.eosinophil chemoattractant and activation factor.cell aggregation and adhesion, as well as apoptosis of tumor cells.Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells.
Biochemical Properties a tandem-repeat type galectin with two carbohydrate-recognition domains.two non-homologous N- and C-terminal CRDs joined by a short polypeptide called the linker domain. four –OH groups of the β-galactoside residue forms the critical hydrogen bonds with highly conserved residues within the galectin CRD.In N terminal carbohydrate recognition domain,hydrogen bond is formed by N and H with O4 of galactose and an additional hydrogen bond between O6 of galactose and N completes the interaction.
Significance in milk Galectin 9 is a tandem repeat member of Gal involved in cell activation, pathogen destruction and immunosuppression.Galectin 9 secretion in cow milk a marker for homostasis and health.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 169-189
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.John S, Mishra R. Galectin-9: From cell biology to complex disease dynamics. J Biosci. 2016 Sep;41(3):507-34. doi: 10.1007/s12038-016-9616-y. PMID: 27581941. 2.Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T. Galectin-9 in cancer therapy. Recent Pat Endocr Metab Immune Drug Discov. 2013 May;7(2):130-7. doi: 10.2174/1872214811307020006. PMID: 23514536. 3.B Mulakala, E Eluka-Okoludoh, S Adjei-Fremah, E Asiamah, K Ekwemalor, H Ismail, S Ibrahim, M Worku, PSVIII-29 Galectin 9 secretion in cow milk a marker for homostasis and health., Journal of Animal Science, Volume 96, Issue suppl_3, December 2018, Pages 30–31, https://doi.org/10.1093/jas/sky404.069