Primary Information |
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| BoMiProt ID | Bomi5926 |
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| Protein Name | Galectin-3-binding protein |
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| Organism | Bos taurus |
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| Uniprot ID | A7E3W2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039781.1 |
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| Aminoacid Length | 555 |
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| Molecular Weight | 62127 |
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| FASTA Sequence |
Download |
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| Gene Name | LGALS3BP |
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| Gene ID | 531137 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | found in most normal adult tissues, mainly in epithelial and myeloid/amoeboid cells. |
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| Protein Function | Promotes integrin-mediated cell adhesion.stimulate host defense against viruses and tumor cells.Gal-3BP can induce galectin-mediated tumor cell aggregation to increase the survival of cancer cells in the bloodstream during the metastatic process. |
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| Biochemical Properties | Homodimers and homomultimers.Interacts with the gamma-tubulin ring complex. |
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| Significance in milk | related to cow milk allergy in children |
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| PTMs | N linked Glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7E3W2|LG3BP_BOVIN Galectin-3-binding protein OS=Bos taurus OX=9913 GN=LGALS3BP PE=1 SV=1
MAPLRLFWIWLLVVGTRGVKDGDMRLADGGSANQGRVEIYYNGQWGTVCENMWDLTDASV
VCRALGFQN*69ATEALGGAAFGPGYGPIMLDEVRCTGTEPSLANCSSLGWMRSNCRHDKDAS
VICTN*125ETRGVYTLDLSGELPAALEQIFESQKGCDLFITVKVREEDEIAMCAHKLILSTNP
EAHGLWKEPGSRVTMEVDAECVPVVKDFIRYLYSRRIDVSLSSVKCLHKLASAYQAKQLQ
SYCGHLFAILIPQDPSFWTPLELYAYALATRDPVLEEICVQFLAWNFGALTQAEAWPSVP
PALLQGLLSRTELVVPSELVLLLAVDKWSQERRTSHKEVEALVGQVRFPMMPPQDLFSLQ
FN*362LSLYWSHEALFQKKILQALEFHTVPFELLAQYWGLN*398LTEGTYQPRLYTSPTWSQSVMS
SSYNPSRSFQTPQHPSFLFHDSSVSWSFVYLPTLQSCWNYGFSCSSDDPPLLALSKSSYS
KSNPTIGYENRALLHCEGSFVVDVIDFKGWKALVPSALATNSSRSTSLFPCPSGVFSRFQ
VVIRPFYLTN*550STDMD |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Lin TW, Chang HT, Chen CH, Chen CH, Lin SW, Hsu TL, Wong CH. Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis. J Am Chem Soc. 2015 Aug 5;137(30):9685-93. doi: 10.1021/jacs.5b04744. Epub 2015 Jul 22. PMID: 26168351. |
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