Primary Information |
---|
BoMiProt ID | Bomi5926 |
---|
Protein Name | Galectin-3-binding protein |
---|
Organism | Bos taurus |
---|
Uniprot ID | A7E3W2 |
---|
Milk Fraction | Whey |
---|
Ref Sequence ID | NP_001039781.1 |
---|
Aminoacid Length | 555 |
---|
Molecular Weight | 62127 |
---|
FASTA Sequence |
Download |
---|
Gene Name | LGALS3BP |
---|
Gene ID | 531137 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Presence in other biological fluids/tissue/cells | found in most normal adult tissues, mainly in epithelial and myeloid/amoeboid cells. |
---|
Protein Function | Promotes integrin-mediated cell adhesion.stimulate host defense against viruses and tumor cells.Gal-3BP can induce galectin-mediated tumor cell aggregation to increase the survival of cancer cells in the bloodstream during the metastatic process. |
---|
Biochemical Properties | Homodimers and homomultimers.Interacts with the gamma-tubulin ring complex. |
---|
Significance in milk | related to cow milk allergy in children |
---|
PTMs | N linked Glycosylation on Asn |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7E3W2|LG3BP_BOVIN Galectin-3-binding protein OS=Bos taurus OX=9913 GN=LGALS3BP PE=1 SV=1
MAPLRLFWIWLLVVGTRGVKDGDMRLADGGSANQGRVEIYYNGQWGTVCENMWDLTDASV
VCRALGFQN*69ATEALGGAAFGPGYGPIMLDEVRCTGTEPSLANCSSLGWMRSNCRHDKDAS
VICTN*125ETRGVYTLDLSGELPAALEQIFESQKGCDLFITVKVREEDEIAMCAHKLILSTNP
EAHGLWKEPGSRVTMEVDAECVPVVKDFIRYLYSRRIDVSLSSVKCLHKLASAYQAKQLQ
SYCGHLFAILIPQDPSFWTPLELYAYALATRDPVLEEICVQFLAWNFGALTQAEAWPSVP
PALLQGLLSRTELVVPSELVLLLAVDKWSQERRTSHKEVEALVGQVRFPMMPPQDLFSLQ
FN*362LSLYWSHEALFQKKILQALEFHTVPFELLAQYWGLN*398LTEGTYQPRLYTSPTWSQSVMS
SSYNPSRSFQTPQHPSFLFHDSSVSWSFVYLPTLQSCWNYGFSCSSDDPPLLALSKSSYS
KSNPTIGYENRALLHCEGSFVVDVIDFKGWKALVPSALATNSSRSTSLFPCPSGVFSRFQ
VVIRPFYLTN*550STDMD |
---|
Predicted Disorder Regions | NA |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Bibliography | Lin TW, Chang HT, Chen CH, Chen CH, Lin SW, Hsu TL, Wong CH. Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis. J Am Chem Soc. 2015 Aug 5;137(30):9685-93. doi: 10.1021/jacs.5b04744. Epub 2015 Jul 22. PMID: 26168351. |