Primary Information |
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BoMiProt ID | Bomi5869 |
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Protein Name | Furin/Dibasic-processing enzyme/Paired basic amino acid residue-cleaving enzyme/Trans Golgi network protease furin |
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Organism | Bos taurus |
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Uniprot ID | Q28193 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_776561.1 |
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Aminoacid Length | 797 |
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Molecular Weight | 87251 |
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FASTA Sequence |
Download |
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Gene Name | FURIN/FUR/PACE |
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Gene ID | 281374 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | almost found in all type tissues,Trans golgi network or endosomal |
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Protein Function | Mediates processing of TGFB1, an essential step in TGF-beta-1 activation.ndoprotease, converts many vasoregulatory propeptides, including pro-transforming growth factor (TGF)-beta to their mature forms. |
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Biochemical Properties | binds to cofactor calcium and Binds 3 calcium ions per subunit.Interacts with FLNA. Binds to PACS1 which mediates TGN localization and connection to clathrin adapters. |
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PTMs | N linked Glycosylation on Asn .Phosphorylation on Ser,autocatalytic cleavage |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 7 disorederes segments; (169-191), (257-266), (342-347), (407-410),(619-627), (672-707), (768-797) |
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DisProt Annotation | |
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TM Helix Prediction | 1TMH; (719 -741) |
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Significance of PTMs | Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.Furin is activated by autocatalytic cleavage of its propeptide, presumably at the -Lys-Arg-Arg-Thr-Lys-Arg−1-↓ site. |
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Bibliography | Negishi M, Lu D, Zhang YQ, Sawada Y, Sasaki T, Kayo T, Ando J, Izumi T, Kurabayashi M, Kojima I, Masuda H, Takeuchi T. Upregulatory expression of furin and transforming growth factor-beta by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2001 May;21(5):785-90. doi: 10.1161/01.atv.21.5.785. PMID: 11348875. |