Search by BoMiProt ID - Bomi5869


Primary Information

BoMiProt ID Bomi5869
Protein Name Furin/Dibasic-processing enzyme/Paired basic amino acid residue-cleaving enzyme/Trans Golgi network protease furin
Organism Bos taurus
Uniprot IdQ28193
Milk FractionWhey
Ref Sequence Id NP_776561.1
Aminoacid Length 797
Molecular Weight 87251
Fasta Sequence https://www.uniprot.org/uniprot/Q28193.fasta
Gene Name FURIN/FUR/PACE
Gene Id 281374
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells almost found in all type tissues,Trans golgi network or endosomal
Protein Function Mediates processing of TGFB1, an essential step in TGF-beta-1 activation.ndoprotease, converts many vasoregulatory propeptides, including pro-transforming growth factor (TGF)-beta to their mature forms.
Biochemical Properties binds to cofactor calcium and Binds 3 calcium ions per subunit.Interacts with FLNA. Binds to PACS1 which mediates TGN localization and connection to clathrin adapters.
PTMs N linked Glycosylation on Asn .Phosphorylation on Ser,autocatalytic cleavage
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 7 disorederes segments; (169-191), (257-266), (342-347), (407-410),(619-627), (672-707), (768-797)
DisProt Annotation
TM Helix Prediction 1TMH; (719 -741)
Significance of PTMs Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.Furin is activated by autocatalytic cleavage of its propeptide, presumably at the -Lys-Arg-Arg-Thr-Lys-Arg−1-↓ site.
Bibliography Negishi M, Lu D, Zhang YQ, Sawada Y, Sasaki T, Kayo T, Ando J, Izumi T, Kurabayashi M, Kojima I, Masuda H, Takeuchi T. Upregulatory expression of furin and transforming growth factor-beta by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2001 May;21(5):785-90. doi: 10.1161/01.atv.21.5.785. PMID: 11348875.