Primary Information
BoMiProt ID	Bomi5864
Protein Name	Fructose-bisphosphate aldolase B/Liver-type aldolase
Organism	Bos taurus
Uniprot ID	Q3T0S5
Milk Fraction	Whey,MFGM
Ref Sequence ID	NP_001029657.1
Aminoacid Length	364
Molecular Weight	39543
FASTA Sequence	Download
Gene Name	ALDOB
Gene ID	515263
Protein Existence Status	reviewed
Secondary Information
Protein Function	involved in glucose and fructose metabolism.negative regulation of Akt activation thus inhibiting hepatic carcinogenesis.Aldob directly binds and inhibits the rate-limiting enzyme in pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD)
Biochemical Properties	tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
PTMs	Acetylation, Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q3T0S5|ALDOB_BOVIN Fructose-bisphosphate aldolase B OS=Bos taurus OX=9913 GN=ALDOB PE=2 SV=1 MAHQFPALTSEQKKALSETARRIVANGKGILAADES*36VGT*39MGNRLQRIKVENTEENRRQFR ELLFTVDSSVSQSIGGVILFHETLYQKDGQGKLFRDILKEKGIVVGIKLDQGVAPLAGT*119NKETTVQGLDGLS*132ERCAQYKKDGADFGKWRAVLKIDNQCPSHLAIQENANTLARYASICQQ NGLVPIVEPEVIPDGSHDMEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLS*272GGMS*276EEDATLNLNAINLCPLPKPWKLS*299F S*301YGRALQAS*309ALAAWGGKAENKKTTQEAFMKRALANSQAAKGQYVHMGSSGSASTQSLFTA SYTY
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	In mammals AldOB is expressed in liver.Veretebrates have 3 isozymes,aldolase A(ALDOA),B (ALDOB), and C (ALDOC)
Bibliography	1.He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H. Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex. PLoS Biol. 2020 Dec 4;18(12):e3000803. doi: 10.1371/journal.pbio.3000803. PMID: 33275593; PMCID: PMC7744066.