Search by BoMiProt ID - Bomi5835


Primary Information

BoMiProt ID Bomi5835
Protein Name Forkhead box protein L2
Organism Bos taurus
Uniprot IDQ6VFT7
Milk FractionWhey
Ref Sequence ID NP_001026920.1
Aminoacid Length 377
Molecular Weight 38887
FASTA Sequence Download
Gene Name FOXL2
Gene ID 281770
Protein Existence Status reviewed

Secondary Information

Protein Function Plays imp role as transcriptional regulator in gonadal sex differentiation. Critical factor essential for ovary differentiation and function, and repression of the genetic program for somatic testis determination.endometrial FOXL2 is, as a direct target of progesterone, involved in early pregnancy and implantation.
Significance in milk FOXL2 is involved in the regulation of endometrial tissue physiology.
PTMs Sumoylated with SUMO1.Phosphorylation on Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q6VFT7|FOXL2_BOVIN Forkhead box protein L2 OS=Bos taurus OX=9913 GN=FOXL2 PE=2 SV=1 MMASYPEPENASGALLAPETGRAAKEPEAPPPPS*34PGKGGGGGTGTAPEKPDPAQKPPYSY VALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREG GGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVA GAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSP GAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHSHPHAHHL HAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTNAPGLQFACARQPELAMMHCS YWDHDSKTGALHSRLDL
Predicted Disorder Regions 4 disordered segments; (3-55), (228-245), (272-284), (366-376)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs sumoylation is required for transcriptional repression activity
Bibliography Eozenou C, Lesage-Padilla A, Mauffré V, Healey GD, Camous S, Bolifraud P, Giraud-Delville C, Vaiman D, Shimizu T, Miyamoto A, Sheldon IM, Constant F, Pannetier M, Sandra O. FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants. Int J Mol Sci. 2020 Feb 21;21(4):1478. doi: 10.3390/ijms21041478. PMID: 32098259; PMCID: PMC7073057.