Search by BoMiProt ID - Bomi5766


Primary Information

BoMiProt ID Bomi5766
Protein Name Fez family zinc finger protein 2/Forebrain embryonic zinc finger-like protein 2/Zinc finger protein 312/Zinc finger protein Fez-like
Organism Bos taurus
Uniprot IdQ2VWH6
Milk FractionWhey
Ref Sequence Id NP_001033287.1
Aminoacid Length 458
Molecular Weight 48842
Fasta Sequence https://www.uniprot.org/uniprot/Q2VWH6.fasta
Gene Name FEZF2/ZNF312/FEZL
Gene Id 613683
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Brain and mammary gland
Protein Function Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons
Significance in milk controls the development of monoaminergic neuron.Bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-26, 40-62,103-117, 265-269
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments FEZL-deficient mice display hyperactive behavior, suggesting that FEZL has a role in neuronal development
Bibliography 1.Sugimoto M, Fujikawa A, Womack JE, Sugimoto Y. Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6454-9. doi: 10.1073/pnas.0601015103. Epub 2006 Apr 12. PMID: 16611727; PMCID: PMC1458905. 2.Sugimoto, M., Fujikawa, A., Womack, J. E., & Sugimoto, Y. (2006). Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6454–6459. https://doi.org/10.1073/pnas.0601015103