Search by BoMiProt ID - Bomi5763


Primary Information

BoMiProt ID Bomi5763
Protein Name Ferroptosis suppressor protein 1/Apoptosis-inducing factor homologous mitochondrion-associated inducer of death/p53-responsive gene 3 protein
Organism Bos taurus
Uniprot IdA5PJM4
Milk FractionWhey
Ref Sequence Id NP_001300960.1
Aminoacid Length 373
Molecular Weight 40477
Fasta Sequence https://www.uniprot.org/uniprot/A5PJM4.fasta
Gene Name AIFM2
Gene Id 534217
Protein Existence Status reviewed

Secondary Information

Protein Function It catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10 at the plasma membrane. It is a NAD(P)H-dependent oxidoreductase and is involved in response against cellular oxidative stress.
Biochemical Properties Binds 6-hydroxy-FAD non-covalently.
PTMs myristoylation,lipidation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (11-33)
Significance of PTMs N-terminus of FSP1 contains a canonical myristoylation motif and myristoylation is a lipid modification that promotes target protein binding to cell membranes.Myristoylation at the N-terminus of the FSP1 protein facilitates the localization of FSP1 to the plasma membrane, which is critical for its ferroptosis-inhibitory activity
Bibliography 1.Wei, X., Yi, X., Zhu, X. H., & Jiang, D. S. (2020). Posttranslational Modifications in Ferroptosis. Oxidative medicine and cellular longevity, 2020, 8832043. https://doi.org/10.1155/2020/8832043 2.Dai, E., Zhang, W., Cong, D., Kang, R., Wang, J., & Tang, D. (2020). AIFM2 blocks ferroptosis independent of ubiquinol metabolism. Biochemical and biophysical research communications, 523(4), 966–971. https://doi.org/10.1016/j.bbrc.2020.01.066