Search by BoMiProt ID - Bomi5727


Primary Information

BoMiProt ID Bomi5727
Protein Name F-box only protein 7
Organism Bos taurus
Uniprot IdQ2T9S7
Milk FractionWhey
Ref Sequence Id NP_001033148.1
Aminoacid Length 522
Molecular Weight 57965
Fasta Sequence https://www.uniprot.org/uniprot/Q2T9S7.fasta
Gene Name FBXO7
Gene Id 508235
Protein Existence Status reviewed

Secondary Information

Protein Function take part in ubiquitination and subsequent proteasomal degradation of target proteins.It is a substrate recognition component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.negatively regulates NF-κB signaling through TRAF2 and cIAP1 ubiquitination.
Biochemical Properties 40–50 amino acid F-box domain that binds to skp1.ubiquitin-like (Ubl) domain at its N-terminus and an unstructured PRR, used to recruit substrates, at its C-terminus
PTMs Methylation on Arg
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 83-147
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Nelson DE, Randle SJ, Laman H. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol. 2013 Oct 9;3(10):130131. doi: 10.1098/rsob.130131. PMID: 24107298; PMCID: PMC3814724. 2.Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR. The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129754. doi: 10.1016/j.bbagen.2020.129754. Epub 2020 Sep 30. PMID: 33010352; PMCID: PMC8063000.