Primary Information
BoMiProt ID	Bomi5727
Protein Name	F-box only protein 7
Organism	Bos taurus
Uniprot ID	Q2T9S7
Milk Fraction	Whey
Ref Sequence ID	NP_001033148.1
Aminoacid Length	522
Molecular Weight	57965
FASTA Sequence	Download
Gene Name	FBXO7
Gene ID	508235
Protein Existence Status	reviewed
Secondary Information
Protein Function	take part in ubiquitination and subsequent proteasomal degradation of target proteins.It is a substrate recognition component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.negatively regulates NF-κB signaling through TRAF2 and cIAP1 ubiquitination.
Biochemical Properties	40–50 amino acid F-box domain that binds to skp1.ubiquitin-like (Ubl) domain at its N-terminus and an unstructured PRR, used to recruit substrates, at its C-terminus
PTMs	Methylation on Arg
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	83-147
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Nelson DE, Randle SJ, Laman H. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol. 2013 Oct 9;3(10):130131. doi: 10.1098/rsob.130131. PMID: 24107298; PMCID: PMC3814724. 2.Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR. The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129754. doi: 10.1016/j.bbagen.2020.129754. Epub 2020 Sep 30. PMID: 33010352; PMCID: PMC8063000.