Search by BoMiProt ID - Bomi5705


Primary Information

BoMiProt ID Bomi5705
Protein Name Fas apoptotic inhibitory molecule 1
Organism Bos taurus
Uniprot IdQ0IIF6
Milk FractionWhey
Ref Sequence Id NP_001073094.1
Aminoacid Length 201
Molecular Weight 22648
Fasta Sequence https://www.uniprot.org/uniprot/Q0IIF6.fasta
Gene Name FAIM
Gene Id 616795
Protein Existence Status reviewed

Secondary Information

Protein Function  inhibit Fas-induced cell death.FAIM1 inhibits Fas ligand- and tumor necrosis factor alpha-induced apoptosis by direct interaction with Fas receptor and through the stabilization of levels of X-linked inhibitor of apoptosis protein, a potent anti-apoptotic protein that inhibits caspases..protect neurons from DR(death receptor)-induced apoptosis and are involved in neurite outgrowth and neuronal plasticity.
Biochemical Properties 20 kDa evolutionary-conserved soluble protein. it contains two independently folding domains. The short isoform, FAIM-S, was first isolated from B-lymphocytes as a protein that conferred resistance to Fas-induced cell death.a longer splice variant that contains 22 additional amino acids on the N-terminal end of the protein was identified and named FAIM-L .the C-terminal domain of FAIM-S folds as a non-conventional β-sandwich, and the crystal structure of the N-terminal domain revealed a similar conformation containing eight antiparallel β-strands
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-19, 177-182, 199-201
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Low FAIM1 levels are found in Alzheimer's disease, thus sensitizing neurons to tumor necrosis factor alpha and prompting neuronal loss.
Bibliography Planells-Ferrer L, Urresti J, Coccia E, Galenkamp KM, Calleja-Yagüe I, López-Soriano J, Carriba P, Barneda-Zahonero B, Segura MF, Comella JX. Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system. J Neurochem. 2016 Oct;139(1):11-21. doi: 10.1111/jnc.13729. Epub 2016 Aug 3. PMID: 27385439.