Search by BoMiProt ID - Bomi5643


Primary Information

BoMiProt ID Bomi5643
Protein Name Exonuclease V/Defects in morphology protein 1 homolog
Organism Bos taurus
Uniprot IdA2VDX7
Milk FractionWhey
Ref Sequence Id NP_001075077.1
Aminoacid Length 370
Molecular Weight 41511
Fasta Sequence https://www.uniprot.org/uniprot/A2VDX7.fasta
Gene Name EXO5/DEM1
Gene Id 538883
Protein Existence Status reviewed

Secondary Information

Protein Function is involved in recombinational repair of double-strand breaks that are caused by defective DNA replication, DNA damaging agents and other factors.
Biochemical Properties heterotrimeric subunit structure and consists of 3 polypeptides,RecB, RecC and RecD.Is capable of unwinding DNA double helix by itsDNA helicase activity.Also contain nuclease activity,which is involved in the digestion of DNA.Binds 1 [4Fe-4S] cluster.Mg2+ in the catalytic centre.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-61, 360-370
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Leung WY, Chung LH, Kava HW, Murray V. RecBCD (Exonuclease V) is inhibited by DNA adducts produced by cisplatin and ultraviolet light. Biochem Biophys Res Commun. 2018 Jan 1;495(1):666-671. doi: 10.1016/j.bbrc.2017.11.060. Epub 2017 Nov 10. PMID: 29129691.