Search by BoMiProt ID - Bomi5640


Primary Information

BoMiProt ID Bomi5640
Protein Name Exocyst complex component 3-like protein
Organism Bos taurus
Uniprot IdQ0VCR8
Milk FractionWhey
Ref Sequence Id NP_001069350.1
Aminoacid Length 739
Molecular Weight 81295
Fasta Sequence https://www.uniprot.org/uniprot/Q0VCR8.fasta
Gene Name EXOC3L1
Gene Id 526306
Protein Existence Status reviewed

Secondary Information

Protein Function A component of exocyst protein,which is a octameric complex involved in docking or tethering of secretory vesicles to fusion sites of the plasma membrane.Also regulates insulin secretion, by translocating GLUT4 transporter.
Biochemical Properties An isoform of Sec6 to regulate insulin secretion in pancreatic β cells.Serine-471 residue is surrounded by a consensus motif of a protein kinase Cζ (PKCζ) phosphorylation site.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Researchers have found that overexpressed EXOC3L1 in Chinese hamster ovary cells significantly reduced cultured cell numbers. It also significantly increased apoptotic DNA ladder, caspase 3 activity, and cleavage of caspase 3 compared with the control.
Bibliography 1.Matsumoto S, Okada J, Yamada E, Saito T, Okada K, Watanabe T, Nakajima Y, Ozawa A, Okada S, Yamada M. Overexpressed exocyst complex component 3-like 1 spontaneously induces apoptosis. Biomed Res. 2021;42(3):109-113. doi: 10.2220/biomedres.42.109. PMID: 34092752.