Primary Information |
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| BoMiProt ID | Bomi5624 |
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| Protein Name | Eukaryotic translation initiation factor 3 subunit M |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T148 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001030389.2 |
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| Aminoacid Length | 373 |
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| Molecular Weight | 42416 |
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| FASTA Sequence |
Download |
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| Gene Name | EIF3M |
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| Gene ID | 515543 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
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| PTMs | Phosphorylation at Ser,N-acetylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3T148|EIF3M_BOVIN Eukaryotic translation initiation factor 3 subunit M OS=Bos taurus OX=9913 GN=EIF3M PE=2 SV=2
MS*2VPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWIS*152DWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLAYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQEL
QIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNL
NKVKNS*366LLSLSDT |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Cheshenko N, Trepanier JB, Segarra TJ, Fuller AO, Herold BC. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. PLoS One. 2010 Jul 27;5(7):e11829. doi: 10.1371/journal.pone.0011829. PMID: 20676407; PMCID: PMC2910742. |
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