Primary Information |
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| BoMiProt ID | Bomi5604 |
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| Protein Name | ETS-related transcription factor Elf-1/E74-like factor 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A0JN51 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001071321.1 |
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| Aminoacid Length | 614 |
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| Molecular Weight | 66572 |
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| FASTA Sequence |
Download |
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| Gene Name | ELF1 |
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| Gene ID | 505251 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | potential downstream target of the DNA damage response pathway, and following ionizing radiation.Report says cells treated with a siRNA against ELF1 were more likely to escape cell cycle arrest by bypassing the G2-M checkpoint which signifies its potential role in cell cycle regulation. |
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| PTMs | Phosphorylation on Ser and Thr, O linked glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A0JN51|ELF1_BOVIN ETS-related transcription factor Elf-1 OS=Bos taurus OX=9913 GN=ELF1 PE=2 SV=1
MAAVVQQNDLVFEFASNVMEDEQQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM
ITESSLDVAEEEIIDEDEDDITLTVEASCHNGDETIETIEAAEALLNMDS*110PGPMLDEKRM
NNSIFSSSEDDMVVAPVTHVSVTLDGIPEVMETQHVQETYAHS*163PGPS*167 S*168PEQPKRKKGRKT
KPPRPDS*187PTT*190TPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKL
VDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKDMPKDLIYID
DEDPSCSIESSDPSLSSTATSSRNPASRSRASSSPGIKGGATTVLKPGNSKAAKPKDPME
PVQPSEALRTVQSTQAPYPTQLFRTIHVVQPVQAVPEAEAASSMPEETLNPSVPSIRTIQ
TPAQVPVVVS*430PGNQHLHTVTLQTVPITTVIASADPSSAAGSQKFILQAIPSSQPMTVLKE
NVVLQSQKPGSPPSIVLSPAHVQQVLTSSVPTVCNGTVSAASAPSFSATTPMVTFSHHSS
QLVAHPPGTVITSVIKAQEAKTHIQEEVKKEVEDNEKQGTEDAEQQLQPYVMVVSNGFPS
QAAIKNELLEPSSF |
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| Predicted Disorder Regions | 63-129, 153-183, 196-199, 318-436, 451-462, 485-510, 522-614 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | Phosphorylation by protein kinase C (PKC) and O-linked glycosylation contribute to the increased posttranslational molecular mass of Elf-1((from 80- to 98-kDa form). glycosylation and phosphorylation are required for Elf-1 to bind the Elf-1 site on the TCR ζ-chain promoter. |
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| Bibliography | 1.Juang YT, Solomou EE, Rellahan B, Tsokos GC. Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain. J Immunol. 2002 Mar 15;168(6):2865-71. doi: 10.4049/jimmunol.168.6.2865. PMID: 11884456. 2.Cheng M, Zeng Y, Zhang T, Xu M, Li Z, Wu Y. Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma. Mol Ther Nucleic Acids. 2020 Oct 15;23:418-430. doi: 10.1016/j.omtn.2020.10.015. PMID: 33473327; PMCID: PMC7787950. |
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