Search by BoMiProt ID - Bomi5600


Primary Information

BoMiProt ID Bomi5600
Protein Name Ethanolamine-phosphate phospho-lyase/Alanine--glyoxylate aminotransferase 2-like 1
Organism Bos taurus
Uniprot IdQ5E9S4
Milk FractionWhey
Ref Sequence Id NP_001015605.1
Aminoacid Length 497
Molecular Weight 55313
Fasta Sequence https://www.uniprot.org/uniprot/Q5E9S4.fasta
Gene Name ETNPPL/AGXT2L1
Gene Id 515186
Protein Existence Status reviewed

Secondary Information

Protein Function  ETNPPL is involved in the catabolism of phosphoethanolamine implicated in membrane synthesis.
Biochemical Properties Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 441-497
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Overexpression of ETNPPL reduces the growth of glioma stem cells indicating that this enzyme opposes gliomagenesis.
Bibliography Leventoux N, Augustus M, Azar S, Riquier S, Villemin JP, Guelfi S, Falha L, Bauchet L, Gozé C, Ritchie W, Commes T, Duffau H, Rigau V, Hugnot JP. Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth. Sci Rep. 2020 Mar 26;10(1):5504. doi: 10.1038/s41598-020-62145-1. PMID: 32218467; PMCID: PMC7099072.