Search by BoMiProt ID - Bomi56


Primary Information

BoMiProt ID Bomi56
Protein Name DnaJ homolog subfamily C member 5
Organism Bos taurus
Uniprot IdQ29455
Milk FractionMFGM, Exosome
Ref Sequence Id NP_776958.2
Aminoacid Length 198
Molecular Weight 22133
Fasta Sequence https://www.uniprot.org/uniprot/Q29455.fasta
Gene Name DNAJC5
Gene Id 282216
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function DnaJ proteins, also known as heat shock protein 40 (Hsp40 or Hsc40) act as cochaperones to the molecular chaperone DnaK (Hsp70), which is responsible for several cellular processes such as rescuing misfolded proteins, folding polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and control of regulatory proteins; primarily facilitates the hydrolysis of ATP from DnaK that is necessary for the chaperone activity of DnaK; DNAJA1 appears to be involved in importing proteins into the mitochondria
Significance in milk heat stress proteins in mamary gland
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (108-130)
Linking IDs
Bibliography 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7.
2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a.