Search by BoMiProt ID - Bomi5597


Primary Information

BoMiProt ID Bomi5597
Protein Name Essential MCU regulator, mitochondrial/Single-pass membrane protein with aspartate-rich tail 1, mitochondrial
Organism Bos taurus
Uniprot IdQ2M2S2
Milk Fractionwhey
Ref Sequence Id NP_001039402.1
Aminoacid Length 107
Molecular Weight 11450
Fasta Sequence https://www.uniprot.org/uniprot/Q2M2S2.fasta
Gene Name SMDT1/EMRE
Gene Id 506149
Protein Existence Status Reviewed

Secondary Information

Protein Function Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
Biochemical Properties It is required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. 
PTMs proteolytic degradation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-6, 27-29, 31-38, 99-107
DisProt Annotation
TM Helix Prediction 1TMH ; (65-83)
Significance of PTMs Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU
Bibliography Xie, K. F., Guo, D. D., & Luo, X. J. (2019). SMDT1-driven change in mitochondrial dynamics mediate cell apoptosis in PDAC. Biochemical and biophysical research communications, 511(2), 323–329. https://doi.org/10.1016/j.bbrc.2019.02.043