Search by BoMiProt ID - Bomi5529


Primary Information

BoMiProt ID Bomi5529
Protein Name EP300-interacting inhibitor of differentiation 2/CREBBP/EP300 inhibitor 2/EID-1-like inhibitor of differentiation 2
Organism Bos taurus
Uniprot IdQ17QW4
Milk FractionWhey
Ref Sequence Id NP_001071517.1
Aminoacid Length 219
Molecular Weight 23882
Fasta Sequence https://www.uniprot.org/uniprot/Q17QW4.fasta
Gene Name EID2
Gene Id 615269
Protein Existence Status reviewed

Secondary Information

Protein Function EID3 is a p300 acetyltransferase inhibitor which can directly regulate DNA methyltransferase 3A (DNMT3A) transdifferentiation into neural stem-like cells (uNSCL) in the umbilical cord mesenchymal stem cells (UMSC).Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation.Inhibits EP300 histone acetyltransferase activity.
PTMs Methylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1 disordered segment; (1-119)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Methylation
Additional Comments EID3 is considered as a potential methylation marker in colon cancer
Bibliography Diao PY, Li SX, Peng J, Yang JH, Pan YC, Xu XP, Tang H, Hu JX, Zhao HF, Huang GD. Overexpression of EP300-interacting inhibitor of differentiation 3 predicts poor prognosis in patients with glioblastoma multiforme. Int J Clin Exp Pathol. 2020 May 1;13(5):979-988. PMID: 32509069; PMCID: PMC7270700.