Search by BoMiProt ID - Bomi5508


Primary Information

BoMiProt ID Bomi5508
Protein Name Endothelin-1
Organism Bos taurus
Uniprot IdP17322
Milk FractionWhey
Ref Sequence Id NP_851353.1
Aminoacid Length 202
Molecular Weight 22977
Fasta Sequence https://www.uniprot.org/uniprot/P17322.fasta
Gene Name EDN1
Gene Id 281137
Protein Existence Status reviewed

Secondary Information

Protein Function Endothelin-1 plays an important role in the pathogenesis of immune-mediated CNS demyelinating diseases by promoting immune responses.ET-1-mediated cellular functions play a critical role in normal pregnancy, preterm birth and uterine leiomyoma.
Biochemical Properties The C-terminal hydrophobic conserved sequence of ET binds to the ET receptors and the N-terminal variable region determines the binding affinity to the receptors.
Significance in milk may play a paracrine regulatory role in bovine luteal function and propose a novel role for this peptide in mediating PGF2alpha-induced luteal regression.
PTMs Phosphorylation at Ser, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 24-47, 98-102, 134-158, 186-188, 192-202
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Proteolytically cleavage by caspases upon induction of apoptosis by TNF.
Additional Comments Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression
Bibliography 1.Tanfin Z, Leiber D, Robin P, Oyeniran C, Breuiller-Fouché M. Endothelin-1: physiological and pathological roles in myometrium. Int J Biochem Cell Biol. 2011 Mar;43(3):299-302. doi: 10.1016/j.biocel.2010.10.009. Epub 2010 Oct 23. PMID: 20974279. 2.Jin YH, Kang B, Kang HS, Koh CS, Kim BS. Endothelin-1 contributes to the development of virus-induced demyelinating disease. J Neuroinflammation. 2020 Oct 17;17(1):307. doi: 10.1186/s12974-020-01986-z. PMID: 33069239; PMCID: PMC7568825. 3.Raina R, Chauvin A, Vajapey R, Khare A, Krishnappa V. Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease . Clin Nephrol. 2019 Jun;91(6):370-379. doi: 10.5414/CN109598. PMID: 30990410.