Search by BoMiProt ID - Bomi5408


Primary Information

BoMiProt ID Bomi5408
Protein Name Ectodysplasin-A/Ectodermal dysplasia protein Ectodysplasin-1/Ectodermal dysplasia protein Ectodysplasin-1
Organism Bos taurus
Uniprot IdQ9BEG5
Milk FractionWhey
Ref Sequence Id NP_001075212.1
Aminoacid Length 391
Molecular Weight 41567
Fasta Sequence https://www.uniprot.org/uniprot/Q9BEG5.fasta
Gene Name EDA
Gene Id 616179
Protein Existence Status reviewed

Secondary Information

Protein Function  induction, morphogenesis and/or maintenance of skin-derived structures such as teeth, hair, sweat glands and several other glands.Deficiencies in the EDA - EDA receptor (EDAR) signalling pathway cause hypohidrotic ectodermal dysplasia (HED).
Biochemical Properties EDA is a 391 amino acid residues-long membrane protein with a short intracellular domain, a transmembrane domain, a stalk region of uncharacterized function, a consensus furin cleavage sequence responsible for proteolytic processing of EDA, a short positively-charged sequence required for interactions with heparan-sulfate proteoglycans, a bi-partite collagen-like domain and a 150 amino acid residues-long C-terminal TNF homology domain (THD) responsible for receptor binding.EDA isoforms (up to nine in mouse keratinocytes), of which only the longest two, EDA1 and EDA2, contain the THD, interact with receptors and are known to be biologically active. EDA1 and EDA2 differ by two amino acid residues in the THD (Glu308 and Val309) as a result of differential usage of a splice donor site at the end of exon 7.
Significance in milk role in the development of skin,hair,teeth and sweat glands
PTMs N-glycosylated on Arg
Additional Comments EDAR agonists may serve to treat certain forms of ectodermal dysplasia.
Linking IDs Bomi5408
Bibliography Kowalczyk-Quintas C, Schneider P. Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation. Cytokine Growth Factor Rev. 2014 Apr;25(2):195-203. doi: 10.1016/j.cytogfr.2014.01.004. Epub 2014 Jan 23. PMID: 24508088.
Protein Function  induction, morphogenesis and/or maintenance of skin-derived structures such as teeth, hair, sweat glands and several other glands.Deficiencies in the EDA - EDA receptor (EDAR) signalling pathway cause hypohidrotic ectodermal dysplasia (HED).
Biochemical Properties EDA is a 391 amino acid residues-long membrane protein with a short intracellular domain, a transmembrane domain, a stalk region of uncharacterized function, a consensus furin cleavage sequence responsible for proteolytic processing of EDA, a short positively-charged sequence required for interactions with heparan-sulfate proteoglycans, a bi-partite collagen-like domain and a 150 amino acid residues-long C-terminal TNF homology domain (THD) responsible for receptor binding.EDA isoforms (up to nine in mouse keratinocytes), of which only the longest two, EDA1 and EDA2, contain the THD, interact with receptors and are known to be biologically active. EDA1 and EDA2 differ by two amino acid residues in the THD (Glu308 and Val309) as a result of differential usage of a splice donor site at the end of exon 7.
Significance in milk role in the development of skin,hair,teeth and sweat glands
PTMs N-glycosylated on Arg
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q9BEG5|EDA_BOVIN Ectodysplasin-A OS=Bos taurus OX=9913 GN=EDA PE=3 SV=2 MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRFSGPGTPGTSGTLSSPGGLDPNGPITRHFGQRSPQQQPLEPGE TTLPPDSQDGHQMALVNFFIPKEKSYSEEESRRVRRNKRSKSSEGADGPVKNKKKGKKAG PPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADK AGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGT YFIYSQVEVYYIN*313FTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKI AVKMVHADISIN*372MSKHTTFFGAIRLGEAPAS
Predicted Disorder Regions 2 disordered segments; (1-35), (71-248)
DisProt Annotation
TM Helix Prediction 1TMH; (42-64)
Additional Comments EDAR agonists may serve to treat certain forms of ectodermal dysplasia.
Linking IDs
Bibliography Kowalczyk-Quintas C, Schneider P. Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation. Cytokine Growth Factor Rev. 2014 Apr;25(2):195-203. doi: 10.1016/j.cytogfr.2014.01.004. Epub 2014 Jan 23. PMID: 24508088.