Search by BoMiProt ID - Bomi5368


Primary Information

BoMiProt ID Bomi5368
Protein Name E3 ubiquitin-protein ligase MARCH8/Membrane-associated RING finger protein 8/Membrane-associated RING-CH protein VIII/RING-type E3 ubiquitin transferase/MARCHF8/MARCH-VIII
Organism Bos taurus
Uniprot IdQ0VD59
Milk FractionWhey
Ref Sequence Id NP_001069700.1
Aminoacid Length 289
Molecular Weight 32780
Fasta Sequence https://www.uniprot.org/uniprot/Q0VD59.fasta
Gene Name MARCHF8/MARCH8
Protein Existence Status reviewed

Secondary Information

Protein Function  ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta.MARCH8, a RING-finger E3 ligase, ubiquitinates Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment
Biochemical Properties The RING-CH-type zinc finger domain is required for E3 ligase activity.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 2 disordered segments;(2-70), (246-284)
DisProt Annotation
TM Helix Prediction 2TMHs; (153-175) and (194-216)