Primary Information
BoMiProt ID	Bomi5364
Protein Name	E3 ubiquitin-protein ligase E3D/Ubiquitin-conjugating enzyme E2C-binding protein/UbcH10-binding protein with a HECT-like domain/HECT-type E3 ubiquitin transferase E3D
Organism	Bos taurus
Uniprot ID	Q1JQA1
Milk Fraction	Whey
Ref Sequence ID	NP_001069179.1
Aminoacid Length	389
Molecular Weight	43392
FASTA Sequence	Download
Gene Name	UBE3D/H10BH/UBE2CBP
Gene ID	515386
Protein Existence Status	reviewed
Secondary Information
Protein Function	role in eye development.UBE3D accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and recognizes the target protein to be degraded.control retinal differentiation and development.
Biochemical Properties	Contains HECT like domain which has the active cysteine residue. Position 235-257 on the C-terminal region of protein is imp for interaction with UBE2C
PTMs	Acetylation, Ubl conjugation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	UBE3D and the ubiquitin-proteasome system may play a role in AMD(Age-related macular degeneration) pathogenic progression.
Bibliography	Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X. ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies. Mol Ther Nucleic Acids. 2020 Jun 5;20:217-230. doi: 10.1016/j.omtn.2020.02.010. Epub 2020 Feb 28. PMID: 32200270; PMCID: PMC7090285.