Search by BoMiProt ID - Bomi5357


Primary Information

BoMiProt ID Bomi5357
Protein Name E3 ubiquitin-protein ligase ARIH1/Protein ariadne-1 homolog/ARI-1/RING-type E3 ubiquitin transferase ARIH1
Organism Bos taurus
Uniprot IdA2VEA3
Milk FractionWhey
Ref Sequence Id NP_001075183.1
Aminoacid Length 555
Molecular Weight 64017
Fasta Sequence https://www.uniprot.org/uniprot/A2VEA3.fasta
Gene Name ARIH1
Gene Id 508410
Protein Existence Status reviewed

Secondary Information

Protein Function E3 ubiquitin ligases .polyubiquitinates damaged mitochondria, leading to their removal via autophagy.protection of cancer cells against genotoxic stress
Biochemical Properties contains RING (really interesting newgene) finger domain, which regulate their interaction with UbcH7.The RING finger domain is a Cys/His-rich, zinc-chelating domain that promotes both protein-protein and protein-DNA interactions.An additional Cys/His-rich region termed as IBR domain is located in between 2 RING domains.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-99, 167-175
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J Biol Chem. 2001 Jun 1;276(22):19640-7. doi: 10.1074/jbc.M011028200. Epub 2001 Mar 13. PMID: 11278816.2.Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier RM, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE. Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells. Cell Rep. 2017 Sep 19;20(12):2846-2859. doi: 10.1016/j.celrep.2017.08.087. PMID: 28930681.