Search by BoMiProt ID - Bomi5330


Primary Information

BoMiProt ID Bomi5330
Protein Name Dynein light chain Tctex-type 1/T-complex testis-specific protein 1 homolog
Organism Bos taurus
Uniprot IdP63171
Milk FractionExosomes
Ref Sequence Id NP_777045.1
Aminoacid Length 113
Molecular Weight 12452
Fasta Sequence https://www.uniprot.org/uniprot/P63171.fasta
Gene Name DYNLT1
Gene Id 282380
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells blood 
Protein Function Dynlt1 modulates orexin signaling by regulating OX1R, namely its intracellular localization following ligand-induced internalization.
PTMs N-acetylation at Meth,Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (1-10)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release.
Bibliography 1.Duguay D, Bélanger-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS One. 2011;6(10):e26430. doi: 10.1371/journal.pone.0026430. Epub 2011 Oct 20. PMID: 22028875; PMCID: PMC3197643.