Search by BoMiProt ID - Bomi5328


Primary Information

BoMiProt ID Bomi5328
Protein Name Dynein light chain roadblock-type 1/Dynein light chain 2A, cytoplasmic
Organism Bos taurus
Uniprot IdQ3T140
Milk FractionExosomes
Ref Sequence Id NP_001029614.1
Aminoacid Length 96
Molecular Weight 10990
Fasta Sequence https://www.uniprot.org/uniprot/Q3T140.fasta
Gene Name DYNLRB1
Gene Id 513342
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells pons 
Protein Function N-acetylglucosamine kinase (NAGK) is a good candidate for promoting dynein activation. Specifically, NAGK interacts with dynein light chain roadblock type 1 (DYNLRB1) to promote dynein functions during mitosis and axonal and dendritic growth.
PTMs N-acetylation at Alanine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-15, 30-41, 92-96
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  NAGK overexpression significantly reduced numbers of dysfunctional spherical mitochondria and increased numbers of ‘thread-like’ healthy mitochondria in our HD(Huntington’s disease) cellular model, which suggests NAGK promoted ALP activity by dynein activation and consequently reduced ROS levels and mitochondrial damage.
Bibliography 1.Islam MA, Sharif SR, Lee H, Seog D-H, Moon IS. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Exp. Mol. Med. 2015;47:e177–e177. 2.Sharif SR, Islam A, Moon IS. N-acetyl-D-glucosamine kinase interacts with dynein-Lis1-NudE1 complex and regulates cell division. Mol. Cells. 2016;39:669–679. 3. Islam MA, Sharif SR, Lee H, Moon IS. N-acetyl-D-glucosamine kinase promotes the axonal growth of developing neurons. Mol. Cells. 2015;38:876–885. 4.Lee H, Cho S-J, Moon IS. The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites. Mol. Cells. 2014;37:248–256.