Search by BoMiProt ID - Bomi5272


Primary Information

BoMiProt ID Bomi5272
Protein Name Doublesex- and mab-3-related transcription factor A2
Organism Bos taurus
Uniprot IdA6QQ94
Milk FractionWhey
Ref Sequence Id NP_001096751.1
Aminoacid Length 535
Molecular Weight 52989
Fasta Sequence https://www.uniprot.org/uniprot/A6QQ94.fasta
Gene Name DMRTA2
Gene Id 537680
Protein Existence Status reviewed

Secondary Information

Protein Function The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1DNA-binding transcription factor activity, RNA polymerase II-specific.RNA polymerase II cis-regulatory region sequence-specific DNA binding
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 4 disordered segments; (10-19), (72-76), (165-308), (356-391)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Dmrta2 knockout accelerates the cell cycle exit and differentiation into postmitotic neurons of NPCs derived from embryonic stem cells and in Emx1-cre conditional mutant mice. 
Bibliography Young FI, Keruzore M, Nan X, Gennet N, Bellefroid EJ, Li M. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5599-E5607. doi: 10.1073/pnas.1705186114. Epub 2017 Jun 27. PMID: 28655839; PMCID: PMC5514752.