Primary Information |
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| BoMiProt ID | Bomi5272 |
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| Protein Name | Doublesex- and mab-3-related transcription factor A2 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QQ94 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001096751.1 |
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| Aminoacid Length | 535 |
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| Molecular Weight | 52989 |
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| FASTA Sequence |
Download |
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| Gene Name | DMRTA2 |
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| Gene ID | 537680 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1DNA-binding transcription factor activity, RNA polymerase II-specific.RNA polymerase II cis-regulatory region sequence-specific DNA binding |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 4 disordered segments; (10-19), (72-76), (165-308), (356-391) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Dmrta2 knockout accelerates the cell cycle exit and differentiation into postmitotic neurons of NPCs derived from embryonic stem cells and in Emx1-cre conditional mutant mice. |
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| Bibliography | Young FI, Keruzore M, Nan X, Gennet N, Bellefroid EJ, Li M. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5599-E5607. doi: 10.1073/pnas.1705186114. Epub 2017 Jun 27. PMID: 28655839; PMCID: PMC5514752. |
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