Search by BoMiProt ID - Bomi5241


Primary Information

BoMiProt ID Bomi5241
Protein Name Dolichol kinase/Transmembrane protein 15
Organism Bos taurus
Uniprot IdQ58CR4
Milk FractionWhey,Exosome,MFGM
Ref Sequence Id NP_001030442.2
Aminoacid Length 538
Molecular Weight 59190
Fasta Sequence https://www.uniprot.org/uniprot/Q58CR4.fasta
Gene Name DOLK/TMEM15
Gene Id 526844
Protein Existence Status reviewed

Secondary Information

Protein Function The synthesis of N-linked and O-linked oligosaccharides and GPI anchors require Dol-P-Man, which is a sugar donor. This enzyme is involved in synthesis of the sugar donor.
PTMs N linked glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 12TMHs; (19 - 37), (110-132), (136-154), (167-185), (225-247), (254-276), (298-316), (336-354), (358-376), (404-422), (437-459),& (479-497)
Significance of PTMs During dilated cardiomyopathy,there is stable and reversible N linked glycosylation.
Additional Comments Autosomal recessive dilated cardiomyopathy has been implicated as a congenital disorder of glycosylation in individuals with mutations in dolichol kinase, an essential enzyme in the biosynthesis of glycan precursors.
Bibliography Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166