Primary Information |
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| BoMiProt ID | Bomi5241 |
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| Protein Name | Dolichol kinase/Transmembrane protein 15 |
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| Organism | Bos taurus |
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| Uniprot ID | Q58CR4 |
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| Milk Fraction | Whey,Exosome,MFGM |
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| Ref Sequence ID | NP_001030442.2 |
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| Aminoacid Length | 538 |
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| Molecular Weight | 59190 |
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| FASTA Sequence |
Download |
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| Gene Name | DOLK/TMEM15 |
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| Gene ID | 526844 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The synthesis of N-linked and O-linked oligosaccharides and GPI anchors require Dol-P-Man, which is a sugar donor. This enzyme is involved in synthesis of the sugar donor. |
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| PTMs | N linked glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 12TMHs; (19 - 37), (110-132), (136-154), (167-185), (225-247), (254-276), (298-316), (336-354), (358-376), (404-422), (437-459),& (479-497) |
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| Significance of PTMs | During dilated cardiomyopathy,there is stable and reversible N linked glycosylation. |
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| Additional Comments | Autosomal recessive dilated cardiomyopathy has been implicated as a congenital disorder of glycosylation in individuals with mutations in dolichol kinase, an essential enzyme in the biosynthesis of glycan precursors. |
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| Bibliography | Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166 |
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