Search by BoMiProt ID - Bomi5233


Primary Information

BoMiProt ID Bomi5233
Protein Name DnaJ homolog subfamily C member 14/J domain protein interacting with viral protein/Jiv
Organism Bos taurus
Uniprot IdQ95J56
Milk FractionWhey
Ref Sequence Id NP_776699.1
Aminoacid Length 699
Molecular Weight 78178
Fasta Sequence https://www.uniprot.org/uniprot/Q95J56.fasta
Gene Name DNAJC14
Gene Id 281691
Protein Existence Status reviewed

Secondary Information

Protein Function Hsp40 chaperone protein.The C-terminus of DNAJC14, which mediates its multimerization, is required for antiviral activity.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 60-193, 212-229, 414-418, 649-653, 672-699
DisProt Annotation
TM Helix Prediction 1TMH; (325-347)
Additional Comments Host protein required for replication of several viruses including yellow fever virus, pestiviruses like bovine viral diarrhea virus (BVDV)
Bibliography 1.Yi Z, Sperzel L, Nürnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, MacDonald MR. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. PLoS Pathog. 2011 Jan 13;7(1):e1001255. doi: 10.1371/journal.ppat.1001255. PMID: 21249176; PMCID: PMC3020928.2.Isken O, Postel A, Bruhn B, Lattwein E, Becher P, Tautz N. CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses. J Virol. 2019 Feb 19;93(5):e01714-18. doi: 10.1128/JVI.01714-18. PMID: 30518653; PMCID: PMC6384085.