Primary Information |
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| BoMiProt ID | Bomi5233 |
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| Protein Name | DnaJ homolog subfamily C member 14/J domain protein interacting with viral protein/Jiv |
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| Organism | Bos taurus |
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| Uniprot Id | Q95J56 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_776699.1 |
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| Aminoacid Length | 699 |
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| Molecular Weight | 78178 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q95J56.fasta |
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| Gene Name | DNAJC14 |
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| Gene Id | 281691 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Hsp40 chaperone protein.The C-terminus of DNAJC14, which mediates its multimerization, is required for antiviral activity. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 60-193, 212-229, 414-418, 649-653, 672-699 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (325-347) |
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| Additional Comments | Host protein required for replication of several viruses including yellow fever virus, pestiviruses like bovine viral diarrhea virus (BVDV) |
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| Bibliography | 1.Yi Z, Sperzel L, Nürnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, MacDonald MR. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. PLoS Pathog. 2011 Jan 13;7(1):e1001255. doi: 10.1371/journal.ppat.1001255. PMID: 21249176; PMCID: PMC3020928.2.Isken O, Postel A, Bruhn B, Lattwein E, Becher P, Tautz N. CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses. J Virol. 2019 Feb 19;93(5):e01714-18. doi: 10.1128/JVI.01714-18. PMID: 30518653; PMCID: PMC6384085. |
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