Search by BoMiProt ID - Bomi5230


Primary Information

BoMiProt ID Bomi5230
Protein Name DnaJ homolog subfamily B member 12
Organism Bos taurus
Uniprot IdQ58DR2
Milk Fractionwhey
Ref Sequence Id NP_001017946.1
Aminoacid Length 370
Molecular Weight 41340
Fasta Sequence https://www.uniprot.org/uniprot/Q58DR2.fasta
Gene Name DNAJB12
Gene Id 533603
Protein Existence Status Reviewed

Secondary Information

Protein Function It acts as a co-chaperone with HSPA8/Hsc70 and is needed to promote protein folding and trafficking, prevent aggregation of target proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway
Biochemical Properties Interacts (via J domain) with HSPA8/Hsc70
PTMs Acetylation and Methylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-6, 20-23, 49-91, 172-196, 361-367
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Yamamoto, Y. H., Kimura, T., Momohara, S., Takeuchi, M., Tani, T., Kimata, Y., Kadokura, H., & Kohno, K. (2010). A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. Cell structure and function, 35(2), 107–116. https://doi.org/10.1247/csf.10023