Search by BoMiProt ID - Bomi5222


Primary Information

BoMiProt ID Bomi5222
Protein Name DNA-directed RNA polymerases I and III subunit RPAC2/RNA polymerases I and III subunit AC2/DNA-directed RNA polymerase I subunit D
Organism Bos taurus
Uniprot IdQ1RMG8
Milk FractionWhey
Ref Sequence Id NP_001069612.1
Aminoacid Length 133
Molecular Weight 15182
Fasta Sequence https://www.uniprot.org/uniprot/Q1RMG8.fasta
Gene Name POLR1D
Gene Id 539061
Protein Existence Status reviewed

Secondary Information

Protein Function DNA dependent RNA polymerase,involved in transcription of DNA into mRNA.Ribosome biogenesis. functional roles in craniofacial morphogenesis.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-36, 121-133
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Treacher Collins syndrome due to mutation or deficiency of this gene
Bibliography Noack Watt KE, Achilleos A, Neben CL, Merrill AE, Trainor PA. The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLoS Genet. 2016 Jul 22;12(7):e1006187. doi: 10.1371/journal.pgen.1006187. PMID: 27448281; PMCID: PMC4957770.