Search by BoMiProt ID - Bomi5200


Primary Information

BoMiProt ID Bomi5200
Protein Name DNA repair protein RAD51 homolog 4/R51H3/RAD51 homolog D/RAD51-like protein 3
Organism Bos taurus
Uniprot IdQ2HJ51
Milk FractionWhey
Ref Sequence Id NP_001039769.1
Aminoacid Length 326
Molecular Weight 34651
Fasta Sequence https://www.uniprot.org/uniprot/Q2HJ51.fasta
Gene Name RAD51D/RAD51L3
Gene Id 529507
Protein Existence Status reviewed

Secondary Information

Protein Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity.
Biochemical Properties The Rad51 protein in eukaryotic cells is a structural and functional homolog of Escherichia coli RecA with a role in DNA repair and genetic recombination.
PTMs Acetylated at Lys-168 and deacetylated at Lys-168 by SIRT3,S-nitrosylation at Cysteine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 315-326
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments In Saccharomyces cerevisiae, two of these proteins, Rad55p and Rad57p, form a heterodimer that can stimulate Rad51-mediated DNA strand exchange.
Bibliography 1.Sigurdsson S, Van Komen S, Petukhova G, Sung P. Homologous DNA pairing by human recombination factors Rad51 and Rad54. J Biol Chem. 2002 Nov 8;277(45):42790-4. doi: 10.1074/jbc.M208004200. Epub 2002 Aug 29. PMID: 12205100. 2.Braybrooke JP, Spink KG, Thacker J, Hickson ID. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. J Biol Chem. 2000 Sep 15;275(37):29100-6. doi: 10.1074/jbc.M002075200. PMID: 10871607.