Search by BoMiProt ID - Bomi5115


Primary Information

BoMiProt ID Bomi5115
Protein Name Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex/Pyruvate dehydrogenase complex component E2/Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Organism Bos taurus
Uniprot IdP11180
Milk FractionWhey
Aminoacid Length 10
Molecular Weight 1066
Fasta Sequence https://www.uniprot.org/uniprot/P11180.fasta
Gene Name DLAT
Gene Id 512723
Protein Existence Status Reviewed

Secondary Information

Protein Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.
PTMs Delipoylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Delipoylated at Lys-5 by SIRT4, delipoylation decreases the PHD complex activity
Bibliography Vijayakrishnan, S., Kelly, S. M., Gilbert, R. J., Callow, P., Bhella, D., Forsyth, T., Lindsay, J. G., & Byron, O. (2010). Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of molecular biology, 399(1), 71–93. https://doi.org/10.1016/j.jmb.2010.03.043