Search by BoMiProt ID - Bomi5100


Primary Information

BoMiProt ID Bomi5100
Protein Name Developmentally-regulated GTP-binding protein 2/Translation factor GTPase DRG2
Organism Bos taurus
Uniprot IdQ58D56
Milk FractionExosomes
Ref Sequence Id NP_001014865.1
Aminoacid Length 364
Molecular Weight 40749
Fasta Sequence https://www.uniprot.org/uniprot/Q58D56.fasta
Gene Name DRG2
Gene Id 507472
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  laryngeal cartilage 
Protein Function Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet.
Biochemical Properties DRG2 does not contain any of these domains and did not bind to any of the PIPs.DRG2 associates with membrane tubules by interacting with proteins on these membrane tubules in a PI4P-dependent manner.
PTMs Hydroxylation at C-3 of Lys-21 by JMJD7, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments The overexpression of DRG2 resulted in an increase in the expression of genes associated with fatty acid synthesis, including acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (Fasn), and a decrease in the expression of carnitine palmitoyltransferase 1 C (CPT1c; a mitochondrial enzyme responsible for lipid oxidation) and aquaporin-7.
Bibliography 1.Park BS, Im HL, Yoon NA, Tu TH, Park JW, Kim JG, Lee BJ. Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation. Biochem Biophys Res Commun. 2021 Nov 12;578:1-6. doi: 10.1016/j.bbrc.2021.08.081. Epub 2021 Aug 29. PMID: 34520979. 2.S. Guo, L.E. Stolz, S.M. Lemrow, J.D. York, SAC1-like domains of yeast SAC1, INP52,and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J.Biol. Chem. 274 (1999) 12990-12995. 3.B.D. Grant, J.G. Donaldson, Pathways and mechanisms of endocytic recycling. Nat.Rev. Mol. Cell Biol. 10 (2009) 597-608.