Primary Information |
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| BoMiProt ID | Bomi5089 |
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| Protein Name | Desmocollin-2 /Epithelial type 2 desmocollin |
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| Organism | Bos taurus |
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| Uniprot ID | P33545 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 863 |
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| Molecular Weight | 95875 |
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| FASTA Sequence |
Download |
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| Gene Name | DSC2 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | heart and skin tissue |
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| Protein Function | Component of intercellular desmosome junctions.Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
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| Biochemical Properties | Calcium may be bound by the cadherin-like repeats.Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.Ser729, Ser733 and Ser738 are conserved between species:human, mouse and bovine. |
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| Significance in milk | desmocollin isoform expression has important functional consequences in epithelial proliferation, stratification, and differentiation.Nutrient delivery. |
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| PTMs | Cleavage on pair of basic residues, Glycosylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P33545|DSC2_BOVIN Desmocollin-2 (Fragment) OS=Bos taurus OX=9913 GN=DSC2 PE=2 SV=1
KFIGRVNLKECFKSATLIHSSDPDFQILEDGSVYTTHAILLSSEKSSFTILLSNTETQEE
KEILVLLEHQTKVLKKRHSQEKVLRRAKRRWAPIPCSVPENSLGPFPLFLQQIQSDTAQN*120
YTIYYSISGPGVDKEPRNLFYVERDTGNLFCTASIDRETYPLFELVAFATTPDGYTPEYP
LTLVIRIEDENDNAPIFTETSYSFEVFENSKVGTTVGQVCATDQDEPDTLHTRLKYSIIE
QFPALPTLFSMHPTTGVITTSSSKLDRELIDKYQLKIKVQDMDGQYFGLQTTAICIINIE
DVNDNLPTFTRSSYVASVEENRIDVEILRVAVRDKDLINTANWRAN*346YTILKGNEDGNFKI
VTDSQTNEGVLCVVKPLNYEEKQQVTLEIGVVNEAPYTGTSRSTTNMATVTVNVQNQDEG
PECDPRVQTVRIKENVPVGTKTIGYKAYDPETGSSSGIRYKKSSDPEGWVDVDKNSGVIT
ILKRLDREARSGVYN*495ISIIASDKDGRTCNGVLGIVLEDVNDNGPVIPQRTVVICKTVMSS
AEIVAVDPDEPIHGPPFDFSLEGVSDSEVLRMWRLTKVN*579DTAARLSYLNDLRFGKYTVPV
RVTDRLGQSLVTQLVVILCDCVTPNDCSFRPVSRTGNREVILGKWAILAILLGIALLFCI
LFTLVCGATTGADKKPKVFPDDLAQQNLIVSNTEAPGDDKVYSTNDFTTHAVGGSAHGIG
GTLGSRVKNGGQETIEMVKGGHQTMESCQETGHDHTLERCKEGGQHTLDSCRGGPVATDN
CKYTYSEWYTYTQPRLGEKVQQCDQDNTHMQAQDYVLTYNYEGRGS*826AAGS*830VGCCS*835ERQEE
DGLEFLDHLGPKFRTLAETCMKR
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; ( 645 - 667) |
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| Significance of PTMs | Ser738 is an expected target for PKC phosphorylation.phosphorylation plays an important role in cell adhesion |
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| Bibliography | Haddad, S. (2006). Phosphorylation of desmocollin 2 in desmosome function. The University of Manchester (United Kingdom). |
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