Primary Information |
|---|
| BoMiProt ID | Bomi5081 |
|---|
| Protein Name | Deoxynucleotidyltransferase terminal-interacting protein 2 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | Q0P5H2 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence Id | NP_001068974.1 |
|---|
| Aminoacid Length | 766 |
|---|
| Molecular Weight | 86798 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/Q0P5H2.fasta |
|---|
| Gene Name | DNTTIP2 |
|---|
| Gene Id | 511258 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | involved in chromatin remodeling and gene transcription.The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. |
|---|
| PTMs | phosphorylation,ubl conjugation,Isopeptide bond formation. |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5H2|TDIF2_BOVIN Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Bos taurus OX=9913 GN=DNTTIP2 PE=2 SV=1
MVVTRSARPQARNEATSVESLRQKNSAVTRLHVHPKGRKGSSPDNPNTTESQTTPERSPA
PKTRKSGTTGSLPEMNKPATDGEISEAESDCSSVPEVQDPVFRVTRRRQILVAGTPVSSV
RKRLKIT*127RVSESHTEEVVS*139EADS*143HVS*146GISRIMPPTEITTRRSKAKSQREPKQESHVEVIS*180DAESSCSDIS*190FSGIATRRTTRSMQRKLQAQTEENNTKIVLENEKEIIHT*229PVNLEDS*236VNRR
TSRLLARS*248LS*250QINKPNFS*258NNEIYNDPDDSFFGISGKKLAVKKTRNFTIREEKQDSISPLK
EITKQNCKSLDEEAKKIIDGGKEGNEKNSQLNLS*334EFQDTGLQQLVSQRHSTPESDKTTSE
SSTLNHEAVMKSLAQTFAVVEMDRWNEERKNAIKTSDCSEPGDGSYSDSDEECTVIGVSE
DMSKEKEVDSESDTKPSNLEFNTTQDKDDSVLLVLSSDESQQSEHSENEEDTVCFVENNG
NKESLNGDSENLSHDNALFVIDTTPGLSADKNFYLDEEDKAGEVATEEEEEEEEEESEEE
LSDHDRNKDNEFSDEDNLLSNTKSKLLKLMSSSIDTGLNIKELGGLYINFNADKVQLNKR
TLTQMKEKRKDELLQKTVIT*620PEFEKNYCVPPYSESKYKLQKKRRQERQKTAGDGWFGMKA
PELTDELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRVPKKQR
KRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN
|
|---|
| Predicted Disorder Regions | 18-25, 42-122, 155-187, 327-353, 381-556, 750-765 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | Fujita K, Shimazaki N, Ohta Y, Kubota T, Ibe S, Toji S, Tamai K, Fujisaki S, Hayano T, Koiwai O. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2003 Jun;8(6):559-71. doi: 10.1046/j.1365-2443.2003.00656.x. PMID: 12786946. |
|---|
