Search by BoMiProt ID - Bomi5077


Primary Information

BoMiProt ID Bomi5077
Protein Name Deoxyhypusine synthase
Organism Bos taurus
Uniprot IDQ6EWQ6
Milk FractionWhey
Ref Sequence ID NP_001003657.1
Aminoacid Length 369
Molecular Weight 41029
FASTA Sequence Download
Gene Name DHPS
Gene ID 444988
Protein Existence Status reviewed

Secondary Information

Protein Function Deoxyhypusine synthase (DHS) first transfers the aminobutyl moiety of spermidine to a specific lysine residue of eIF5A, forming deoxyhypusine which is subsequently hydroxylated by deoxyhypusine hydroxylase (DOHH).
Biochemical Properties utilise NAD as cofactor
PTMs phosphorylation on Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q6EWQ6|DHYS_BOVIN Deoxyhypusine synthase OS=Bos taurus OX=9913 GN=DHPS PE=2 SV=2 MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFG RAVQQVNAMIEKKLEPLS*78EDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLV QHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFE DWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGS LGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGA DYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVD AFMPEKNED
Predicted Disorder Regions 1-10, 77-91, 316-319, 362-368
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylated by PKC which has a possible regulation in the interaction with eIF5A precursor for hypusine synthesis.
Bibliography Kang KR, Kim JS, Chung SI, Park MH, Kim YW, Lim D, Lee SY. Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as well as in vitro. Exp Mol Med. 2002 Dec 31;34(6):489-95. doi: 10.1038/emm.2002.68. PMID: 12526092.