Search by BoMiProt ID - Bomi5076


Primary Information

BoMiProt ID Bomi5076
Protein Name Deoxyhypusine hydroxylase/Deoxyhypusine dioxygenase/Deoxyhypusine monooxygenase
Organism Bos taurus
Uniprot IdQ0VC53
Milk FractionExosomes
Ref Sequence Id NP_001069354.1
Aminoacid Length 303
Molecular Weight 33261
Fasta Sequence https://www.uniprot.org/uniprot/Q0VC53.fasta
Gene Name DOHH
Gene Id 526521
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells longissimus thoracis muscle
Protein Function  Deoxyhypusine hydroxylase (DOHH) is a fundamental enzyme catalyzing a unique posttranslational hypusination modification of eukaryotic translation initiation factor 5A (eIF5A) and is highly involved in the progression of several human diseases, including HIV-1 infection, cancer, malaria, and diabetes. 
Biochemical Properties DOHH comprises a pseudosymmetric arrangement of an N-terminal domain (DOHH-N, amino acids 1–151) and a C-terminal domain (DOHH-C, amino acids 152–302), each consisting of four HEAT repeats (α-hairpins) for a total of 16 α-helices.
PTMs N-acetylation at Meth
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 137-152
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, Yang H, Liu TT, Shi LY, Shi XM, Liu D, Tu PF, Zeng KW. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacol Res. 2022 Feb;176:106046. doi: 10.1016/j.phrs.2021.106046. Epub 2022 Jan 7. PMID: 35007708. 2.Close Z. Han, N. Sakai, L.H. Böttger, S. Klinke, J. Hauber, A.X. Trautwein, R. Hilgenfeld.Crystal structure of the peroxo-diiron(III) intermediate of deoxyhypusine hydroxylase, an oxygenase involved in hypusination Structure, 23 (2015), pp. 882-892.