Primary Information |
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| BoMiProt ID | Bomi5044 |
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| Protein Name | Dehydrogenase/reductase SDR family member 7B/short-chain dehydrogenase/reductase SDR family member 7B |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T0R4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030420.1 |
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| Aminoacid Length | 325 |
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| Molecular Weight | 35032 |
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| FASTA Sequence |
Download |
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| Gene Name | DHRS7B/SDR32C1 |
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| Gene ID | 522283 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of steroids, oxysterols, bile acids, and retinoids in peripheral tissues, thereby controlling the local activation of their cognate receptors. |
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| Biochemical Properties | A short chain dehydrogenase/reductase NcmD was proposed to catalyze the conversion of the hydroxyl group to ketone at the C-10 position. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-8, 315-325 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (19-41) |
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| Additional Comments | SDRs are considered as promising therapeutic targets, for example to treat estrogen-/androgen-dependent and corticosteroid-related diseases, whereas others are considered as anti-targets as their inhibition may lead to disturbances of endocrine functions, thereby contributing to the development and progression of diseases. |
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| Bibliography | 1.Beck KR, Kaserer T, Schuster D, Odermatt A. Virtual screening applications in short-chain dehydrogenase/reductase research. J Steroid Biochem Mol Biol. 2017 Jul;171:157-177. doi: 10.1016/j.jsbmb.2017.03.008. Epub 2017 Mar 9. PMID: 28286207; PMCID: PMC6831487. |
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