Primary Information |
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| BoMiProt ID | Bomi5003 |
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| Protein Name | Cytoskeleton-associated protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A5D7U0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091501.1 |
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| Aminoacid Length | 625 |
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| Molecular Weight | 70085 |
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| FASTA Sequence |
Download |
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| Gene Name | CKAP2 |
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| Gene ID | 515249 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | found in retinal capillary endothelial cells |
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| Protein Function | plays important role in cell proliferation.Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner |
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| Biochemical Properties | Associates with alpha- and beta-tubulins. |
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| Significance in milk | Cytoskeletal protein |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A5D7U0|CKAP2_BOVIN Cytoskeleton-associated protein 2 OS=Bos taurus OX=9913 GN=CKAP2 PE=2 SV=1
MSTPAIPQDLQLNPSQRTQSAFREQRRQKLKEHLLKRKTSFACKQENQMLLSDGDQRVRT
SEGQIQEGKKVLKIKTEMADKENVGRPTGIKNNLTVEKNCIPLKPSNELTNSTLATDPPN
SEDNNQTLPLLPVKDDPQSQHRTLSQTFHLKNNSKKKPVITEKPKHDANVPKKPVLGAYR
GQIVQSKINS*190FRKPLQVKDESSATTKKLPATVSKATKPQPGDVSSITVKSDRASHMTSTT
KFASTTSQIRHLVRPPIRSQHNKAQDAMKPGNSRMSANVTVQKGPREKELNTVLSGIKTS
SSQDIKGDKTLSKSMAAGMVVRPASSSNTKLIEKSKSAGQRSHTTVKAAVDSRWTQPKET
AEERKARLSEWKAGKGRILKRPPSSAVTRPEPETQNEQPVGSFWTTMAEEDEQRLFTEKV
NKTFSECLNLINEPIEEMRHTIVDILTRKSQEKLKFGENIEETSAAEEKIQEAHTDDTGV
DLESGKLEMENNPPRNVFQDCEKEQDDKVKDPTSDVKT*518PST*521NTRAGCLIKYNVS*534T*535T*536PY*538LQS*541VKKKMQFDETNSAYKELKFLTPVRRSRRLQEKTSKLPDMLKDHYPCVSSLEQLTELGCE
TDAFVCRPNTALCGMFSEPDPTEEE
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| Predicted Disorder Regions | 11 predicted disorder segments ;(3rd residue),(38-41),(105-111),(125-139),(154-166),(196-238),(299-345),(362-376),(403-410),(460-523),(616-623) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Zhang S, Wang Y, Chen S, Li J. Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells. Biomed Pharmacother. 2018 Oct;106:1396-1403. doi: 10.1016/j.biopha.2018.07.104. Epub 2018 Jul 23. PMID: 30119212. |
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