Primary Information |
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| BoMiProt ID | Bomi4994 |
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| Protein Name | Cytochrome P450 2U1/Long-chain fatty acid omega-monooxygenase |
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| Organism | Bos taurus |
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| Uniprot ID | Q0IIF9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069518.1 |
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| Aminoacid Length | 543 |
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| Molecular Weight | 61997 |
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| FASTA Sequence |
Download |
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| Gene Name | CYP2U1 |
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| Gene ID | 535227 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates.Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients |
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| Biochemical Properties | CYPs are a superfamily of enzymes with related catalysis to endogenous and exogenous bioactive substances, including xenobiotic metabolism, drugs, and some endogenous substances metabolism which activate cells and stimulate cell signaling pathways, such as arachidonic acid metabolism, steroid metabolism, fatty acid metabolism. Catalyses the following reaction- ω-methyl-long-chain fatty acid + O2 + reduced [NADPH—hemoprotein reductase] = an ω-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH—hemoprotein reductase] |
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| PTMs | Phosphorylation at Ser/Tyr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | (1-12) |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (34-52) and (59-77) |
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| Additional Comments | Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix. |
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| Bibliography | 1.Dhers L, Ducassou L, Boucher JL, Mansuy D. Cytochrome P450 2U1, a very peculiar member of the human P450s family. Cell Mol Life Sci. 2017 May;74(10):1859-1869. doi: 10.1007/s00018-016-2443-3. Epub 2017 Jan 12. PMID: 28083596. 2.Luo B, Chen C, Wu X, Yan D, Chen F, Yu X, Yuan J. Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients. Front Oncol. 2020 Aug 5;10:1379. doi: 10.3389/fonc.2020.01379. PMID: 32850442; PMCID: PMC7419690. |
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