Search by BoMiProt ID - Bomi4976


Primary Information

BoMiProt ID Bomi4976
Protein Name Cysteine--tRNA ligase, mitochondrial/Cysteinyl-tRNA synthetase/CysRS
Organism Bos taurus
Uniprot IdQ2KIF8
Milk FractionWhey
Aminoacid Length 555
Molecular Weight 61199
Fasta Sequence https://www.uniprot.org/uniprot/Q2KIF8.fasta
Gene Name CARS2
Gene Id 506598
Protein Existence Status reviewed

Secondary Information

Protein Function involved in mitochondrial biogenesis and bioenergetics via CysSSH(Cysteine hydropersulfide) production,which are essential structural components of several proteins and enzymes, e.g. serving as metal ligands in iron-sulfur clusters (or sulfide donors) and in iron-cysteine and zinc-cysteine complex.
Biochemical Properties  Binds 1 zinc ion per subunit.Recognizes tRNA-Cys and utilizes ATP as cofactor and L-Cysteine as substrate to form L-cysteinyl-tRNA-Cys.
Significance in milk hydrolyzing casein
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y. PMID: 29079736; PMCID: PMC5660078.