Search by BoMiProt ID - Bomi4969


Primary Information

BoMiProt ID Bomi4969
Protein Name Cysteine dioxygenase type 1
Organism Bos taurus
Uniprot IdQ3SZU4
Milk FractionWhey
Ref Sequence Id NP_001029637.1
Aminoacid Length 200
Molecular Weight 23013
Fasta Sequence https://www.uniprot.org/uniprot/Q3SZU4.fasta
Gene Name CDO1
Protein Existence Status reviewed

Secondary Information

Protein Function This protein catalyses the synthesis of hypotaurine from L-cysteine. It is a subpathway under the taurine biosynthesis.
Biochemical Properties Binds 1 Fe cation per subunit.
PTMs Thio-ether crosslink
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 2 disordered segments; (1-8), (194-200)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Between the residues Cys-93 and Tyr-157 , the thioether linkage plays an important structural role via stabilization of the Fe2+ ion. It also prevents the production of ROS i.e. free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
Bibliography Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166