Search by BoMiProt ID - Bomi4948


Primary Information

BoMiProt ID Bomi4948
Protein Name Cyclic nucleotide-gated olfactory channel/Cyclic nucleotide-gated cation channel 2/Cyclic nucleotide-gated channel alpha-2
Organism Bos taurus
Uniprot IDQ03041
Milk FractionWhey
Ref Sequence ID NP_001001139.1
Aminoacid Length 663
Molecular Weight 76014
FASTA Sequence Download
Gene Name CNGA2/CNCG2
Gene ID 407172
Protein Existence Status reviewed

Secondary Information

Protein Function are excellent targets of various cellular signals to finely regulate neuronal responses to external stimuli. Numerous mechanisms, including transcriptional control, trafficking, as well as channel assembly and modification, underlie HCN channel regulation.
Biochemical Properties HCN channels belong to the superfamily of voltage-gated pore loop channels with four pore-forming subunits (HCN1-4) encoded by the HCN1-4 gene family in mammals . Each subunit has six transmembrane helices (S1-S6), with the positively charged voltage sensor (S4) and the pore region carrying the GYG motif between S5 and S6, which forms the ion selectivity filter. Following S6 is the 80-residue C-linker comprising six alpha-helices (A’-F’) and the cyclic nucleotide-binding domain (CNBD). The CNBD consists of three alpha-helices (A-C) and a β-roll between the A- and B-helices
PTMs N linked glycosylation at Aspn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q03041|CNGA2_BOVIN Cyclic nucleotide-gated olfactory channel OS=Bos taurus OX=9913 GN=CNGA2 PE=1 SV=1 MTEKANGVKSSPANNHNHHAPPAIKASGKDDHRASSRPQSAAADDTSSELQQLAEMDAPQ QRRGGFRRIARLVGVLREWAYRNFREEEPRPDSFLERFRGPELHTVTTQQGDGKGDKDGE GKGTKKKFELFVLDPAGDWYYRWLFLIALPVLYNWCLLVARACFSDLQKGYYIVWLVLDY VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTMQFKLDVASIIPTDLIYFAVGI HNPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLILYILIIIHWNACIYYAISKSI GFGVDTWVYPNITDPEYGYLSREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG VLIFATIVGNVGSMISNMN*379ATRAEFQAKIDAVKHYMQFRKVSKEMEAKVIRWFDYLWTNK KSVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDY ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI RSLGYSDLFCLSKDDLMEAVTEYPDAKRVLEERGREILMKEGLLDENEVAASMEVDVQEK LEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNNEDDSLSDGMNSPEPPA EKP
CATH Matched CATH superfamily
1.10.238.10
Predicted Disorder Regions 1-65, 104-123, 637-663
DisProt Annotation
TM Helix Prediction 4TMHs; (143-161),(170-188),(275-297),(350-372)
Significance of PTMs The assembly of hippocampal HCN1/HCN2 heteromeric channels was increased following the febrile seizure, probably mediated by the increased abundance of HCN2 subunits relative to HCN1 and the network activity-dependent glycosylation of HCN1 channels
PDB ID 1SY9,
Bibliography 1.He C, Chen F, Li B, Hu Z. Neurophysiology of HCN channels: from cellular functions to multiple regulations. Prog Neurobiol. 2014 Jan;112:1-23. doi: 10.1016/j.pneurobio.2013.10.001. Epub 2013 Oct 29. PMID: 24184323. 2.Brewster, A. L., Bernard, J. A., Gall, C. M. and Baram, T. Z. (2005) Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis 19, 200-207. 3.Zha, Q., Brewster, A. L., Richichi, C., Bender, R. A. and Baram, T. Z. (2008) Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem 105, 68-77.