Primary Information |
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| BoMiProt ID | Bomi4903 |
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| Protein Name | Craniofacial development protein 2/p97 bucentaur protein |
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| Organism | Bos taurus |
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| Uniprot ID | O02751 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777225.1 |
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| Aminoacid Length | 592 |
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| Molecular Weight | 66325 |
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| FASTA Sequence |
Download |
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| Gene Name | CFDP2/BCNT |
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| Gene ID | 286876 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | CFDP2,is the 1st identified member of BCNT protein superfamily,discovered in bovine brain,plays roles in chromatin organization.The Drosophila BCNT ortholog, called YETI,is essential for proper fly development . |
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| Biochemical Properties | It consisted of an acidic N-terminal region, a retrotransposon-derived 325-amino acid region (the RTE domain) and of two 40-amino acid intrarepeat (IR) units. The RTE domain was 72 % identical to that of a ruminant specific retrotransposon, called Bov-B LINE. The ~175-amino acid N-terminal portion of the three BCNT-related proteins is acidic as a whole but contains several arginine/lysine-rich elements, including a putative nuclear targeting motif of Arg-Lys-Arg-Lys (~61–64th). |
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| PTMs | Phosphorylation,Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-229, 466-475, 504-511, 530-574 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | phosphoproteins potentially phosphorylated in vitro on serine residues by the casein kinase II. two phosphorylated serine residues in human BCNT, Ser-116 in the N-terminal region and Ser-250 in the C-terminal region.Human and bovine BCNTs were found to be substrates for in vitro acetylation by the co-transcriptional activator CBP/p300, resulting in the acetylation of at least 15 lysine residues |
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| Additional Comments | Expressed in liver and lung with higher expression in brain. |
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| Bibliography | 1.Messina G, Celauro E, Atterrato MT, Giordano E, Iwashita S, Dimitri P. The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function. Chromosoma. 2015 Jun;124(2):153-62. doi: 10.1007/s00412-014-0503-8. Epub 2014 Dec 31. PMID: 25547403. |
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