Search by BoMiProt ID - Bomi4889


Primary Information

BoMiProt ID Bomi4889
Protein Name Coronin-2A
Organism Bos taurus
Uniprot IdQ32LP9
Milk FractionWhey,MFGM
Ref Sequence Id NP_001033309.1
Aminoacid Length 525
Molecular Weight 59845
Fasta Sequence https://www.uniprot.org/uniprot/Q32LP9.fasta
Gene Name CORO2A
Gene Id 617620
Protein Existence Status reviewed

Secondary Information

Protein Function Coronins are conserved F-actin-binding proteins that are important for motility and actin dynamics. coronin 2A acts as a factor that can regulate a subset of focal-adhesion-turnover events.
Biochemical Properties  coronin 2A (CORO2A), a component of the NCoR complex of previously unknown function, mediates TLR-induced NCoR turnover by a mechanism involving interaction with oligomeric nuclear actin. 
PTMs SUMOylation by the SUMO protease SENP3
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 367-386, 396-456
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs SUMOylated LXRs block NCoR turnover by binding to a conserved SUMO2/SUMO3-interaction motif in CORO2A and preventing actin recruitment. 
Additional Comments Coronin 2A is associated with the malignant phenotype of human colon carcinoma.Coronin is linked with 2A to MAPK14 and PRMT5 signalling pathways involved in tumour progression.
Bibliography 1.Marshall TW, Aloor HL, Bear JE. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. J Cell Sci. 2009 Sep 1;122(Pt 17):3061-9. doi: 10.1242/jcs.051482. Epub 2009 Aug 4. PMID: 19654210; PMCID: PMC2729258. 2.Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17;470(7334):414-8. doi: 10.1038/nature09703. PMID: 21331046; PMCID: PMC3464905. 3.Rastetter RH, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, Hojeili S, Bhattacharya K, Wunderlich CM, Wunderlich FT, Odenthal M, Ziemann A, Eichinger L, Clemen CS. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015 Sep 15;15:638. doi: 10.1186/s12885-015-1645-7. PMID: 26373535; PMCID: PMC4612562.