Search by BoMiProt ID - Bomi4878


Primary Information

BoMiProt ID Bomi4878
Protein Name COP9 signalosome complex subunit 4
Organism Bos taurus
Uniprot IdQ3SZA0
Milk FractionExosomes,MFGM
Ref Sequence Id NP_001029866.1
Aminoacid Length 406
Molecular Weight 46285
Fasta Sequence https://www.uniprot.org/uniprot/Q3SZA0.fasta
Gene Name COPS4
Gene Id 540223
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells spermatid
Protein Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes
Biochemical Properties The complex is composed of eight subunits, CSN1-CSN8. Six (CSN1-CSN4, CSN7 and CSN8) contain a PCI (Proteasome, COP9 signalosome and eukaryotic initiation factor 3, eIF3) domain, and two (CSN5 and CSN6) contain a MPN (Mpr1p-Pad1p-N-terminal) domain2. In Arabidopsis, the PCI domain-containing subunits are encoded by single copy genes, while the MPN domain-containing subunits are each encoded by two highly homologous genes. 
PTMs N-acetylation at Ala
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Pacurar DI, Pacurar ML, Lakehal A, Pacurar AM, Ranjan A, Bellini C. The Arabidopsis Cop9 signalosome subunit 4 (CNS4) is involved in adventitious root formation. Sci Rep. 2017 Apr 4;7(1):628. doi: 10.1038/s41598-017-00744-1. Erratum in: Sci Rep. 2017 Jul 20;7(1):6435. PMID: 28377589; PMCID: PMC5429640. 2.Oron E, Mannervik M, Rencus S, Harari-Steinberg O, Neuman-Silberberg S, Segal D, Chamovitz DA. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. Development. 2002 Oct;129(19):4399-409. doi: 10.1242/dev.129.19.4399. PMID: 12223399. 3.Kotiguda GG, et al. The organization of a CSN5-containing subcomplex of the COP9 signalosome. J. Biol. Chem. 2012;287:42031–42041. doi: 10.1074/jbc.M112.387977.