Search by BoMiProt ID - Bomi4810


Primary Information

BoMiProt ID Bomi4810
Protein Name Collagen alpha-1(X) chain
Organism Bos taurus
Uniprot IdP23206
Milk FractionWhey
Ref Sequence Id NP_777059.1
Aminoacid Length 674
Molecular Weight 65546
Fasta Sequence https://www.uniprot.org/uniprot/P23206.fasta
Gene Name COL10A1
Gene Id 282416
Protein Existence Status reviewed

Secondary Information

Protein Function Synthesis of Collagen X is related to differnetiation matiration and proliferation of chondrocytes( Chondrocyte hypertrophy).An increase in the number of matrix vesicles,an increase in alkaline phosphatase activity and the generation of a calcified matrix, which is subsequently replaced by bone.
Biochemical Properties A homotrimer condensed structure. short triple helical collagen domain flanked by the N-terminal NC2 and the C-terminal NC1 domains. The C-terminal NC1 domain has complement C1q-like structure.Collagen X forms hexamer complexes through the association of NC1 regions.The overlapping cDNA clones encode 3144 bp with a 5'-terminal untranslated region of 148 bp, a 2025 bp reading frame and a 3'-terminal untranslated region of 971 bp.The interchain disulphide-bonding observed previously within the triple helix of bovine type X collagen is explained by the presence of two cysteine residues within an imperfection of the triple-helical domain encoded by -Gly-Xaa-Cys-Xaa-Yaa-Cys-Xaa-Yaa-Gly-.
PTMs Hydroxylation on Pro-460 and Pro0463
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Bibliography Thomas JT, Kwan AP, Grant ME, Boot-Handford RP. Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes. Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):141-8. doi: 10.1042/bj2730141. PMID: 1703407; PMCID: PMC1149890.