Primary Information |
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| BoMiProt ID | Bomi4751 |
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| Protein Name | Coagulation factor XIII A chain/Coagulation factor XIIIa/Protein-glutamine gamma-glutamyltransferase A chain/Transglutaminase A chain |
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| Organism | Bos taurus |
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| Uniprot ID | P12260 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 198 |
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| Molecular Weight | 22745 |
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| FASTA Sequence |
Download |
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| Gene Name | F13A1/F13A |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
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| Biochemical Properties | Catalyses L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N6-5-L-glutamyl-[protein] + NH4+. Binds 1 Ca2+ ion per subunit. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1 predicted disorder segment;(1-35) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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