Search by BoMiProt ID - Bomi4734


Primary Information

BoMiProt ID Bomi4734
Protein Name Claudin-4
Organism Bos taurus
Uniprot IDQ6BBL6
Milk FractionExosomes
Ref Sequence ID NP_001014413.1
Aminoacid Length 209
Molecular Weight 22165
FASTA Sequence Download
Gene Name CLDN4
Gene ID 414921
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells placenta
Protein Function claudin-4 is a transmembrane protein that plays an important role in tight junctions.Claudin-4 regulates cell proliferation, invasion, migration and apoptosis.
PTMs Disulfide bond formation, Phosphorylation at Tyr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q6BBL6|CLD4_BOVIN Claudin-4 OS=Bos taurus OX=9913 GN=CLDN4 PE=2 SV=1 MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG QMQCKVYDSLLALPQDLQAARALIVICIILAVFGVLLSVVGGKCTNCVDDESSKAKIMIV AGVVFLLAGLLVMVPVSWTANNVIRDFYNPLVASGQKREMGASLYVGWAAAGLLILGGAL LCFNCPPRNDKPYSAKYSAARSAPASNY*208V
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 4TMHs; (4-26),(82-100),(119-141),(161-183)
Significance of PTMs Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Additional Comments Claudin-4 expression is widely dysregulated in epithelial malignancies and in a number of premalignant precursor lesions.
Bibliography 1.Liu W, Li M. The role of claudin-4 in the development of gastric cancer. Scand J Gastroenterol. 2020 Sep;55(9):1072-1078. doi: 10.1080/00365521.2020.1795923. Epub 2020 Jul 25. PMID: 32715822. 2.Neesse A, Griesmann H, Gress TM, Michl P. Claudin-4 as therapeutic target in cancer. Arch Biochem Biophys. 2012 Aug 1;524(1):64-70. doi: 10.1016/j.abb.2012.01.009. Epub 2012 Jan 24. PMID: 22286027.